Amitriptyline contains Amitriptyline, a tricyclic antidepressant. It has anticholinergic and sedative properties. It prevents the reuptake, and hence the inactivation of neurotransmitters called noradrenaline and serotonin, that are present at the nerve terminals in our brain. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity and helps in regulating the mood. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).
Common side effects of Amitriptyline
Constipation, Dryness in mouth, Orthostatic hypotension (sudden lowering of blood pressure on standing), Weight gain, Aggressive behavior, Nasal congestion (stuffy nose), Sleepiness, Dizziness, Headache, Decreased libido, Nausea, Fatigue, Confusion, Tremors, Speech disorder, Palpitations, Taste change, Paresthesia (tingling or pricking sensation), Abnormality of voluntary movements, Loss of accommodation, Atrioventricular block, Micturition disorders, Erectile dysfunction, Abnormal ECG, Decreased sodium level in blood
